Recent advances in the development of inhibitors targeting KRAS-G12C and its related pathways.

Abstract excerpt

The RAS gene, also known as the mouse sarcoma virus, includes three genes (KRAS, HRAS, and NRAS) that are associated with human tumors. Among them, KRAS has the highest incidence of mutations in cancer, accounting for around 80% of cases. At the molecular level, the RAS gene plays a regulatory role in transcription and translation, while at the cellular level, it affects cell proliferation and migration, making...

Topics

Join the communities discussing this publication.

• Cell Proliferation
• Mice
• Mutation
• Neoplasms
• Proto-Oncogene Proteins p21(ras)