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Article

Selection of genotypes harbouring mutations in the cytochrome b gene of Theileria annulata is associated with resistance to buparvaquone.

PloS one - 1 Jan 2023

Hacılarlıoglu Selin, Bilgic Huseyin Bilgin, Bakırcı Serkan, Tait Andrew, Weir William, Shiels Brian, Karagenc Tulin

Abstract excerpt

Buparvaquone remains the only effective therapeutic agent for the treatment of tropical theileriosis caused by Theileria annulata. However, an increase in the rate of buparvaquone treatment failures has been observed in recent years, raising the possibility that resistance to this drug is associated with the selection of T. annulata genotypes bearing mutation(s) in the cytochrome b gene (Cyto b). The aim of the...

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PMID: 36598898
DOI: 10.1371/journal.pone.0279925

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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