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Systematic review on buparvaquone resistance associated with non-synonymous mutation in drug binding genes site of Theileria annulate.

Veterinary parasitology - 1 Dec 2024

Rashid Muhammad, Hayat Muhammad Hassan, Zahra Naveed, Khan Mian Sayed, Suleman, Nadeem Muhammad, Rehman Tauseef Ur, Ehsan Muhammad, Malik Muhammad Irfan, Obaid Muhammad Kashif, Bakhsh Amir, Darghouth Mohamed Aziz, Ren Qiaoyun

Abstract excerpt

Theileria annulata (T. annulata) is intra-erythrocytic protozoan parasite which is more prevalent in tropical and sub-tropical countries. It has a significant economic impact on the productivity of the dairy industry, and buparvaquone is used to treat infected animals in the prevalent regions of the world. Systematically, buparvaquone targets the cyto-b gene to break the electron transport chain (ETC) and...

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PMID: 39418760
DOI: 10.1016/j.vetpar.2024.110321

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