Article
GAPR-1 Interferes with Condensate Formation of Beclin 1 in Saccharomyces cerevisiae.
Journal of molecular biology - 28 Feb 2023
Sirati Nafiseh, Shen Ziying, Olrichs Nick K, Popova Blagovesta, Verhoek Iris C, Lagerwaard Ilse M, Braus Gerhard H, Kaloyanova Dora V, Helms J Bernd
Abstract excerpt
Golgi-Associated plant Pathogenesis Related protein 1 (GAPR-1) acts as a negative regulator of autophagy by interacting with Beclin 1 at Golgi membranes in mammalian cells. The molecular mechanism of this interaction is largely unknown. We recently showed that human GAPR-1 (hGAPR-1) has amyloidogenic properties resulting in the formation of protein condensates upon overexpression in Saccharomyces cerevisiae. Here...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.