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Profiling placental DNA methylation associated with maternal SSRI treatment during pregnancy

30 Dec 2022

Abstract excerpt

Selective serotonin reuptake inhibitors (SSRIs) for treatment of prenatal maternal depression have been associated with neonatal neurobehavioral disturbances, though the molecular mechanisms remain poorly understood. In utero exposure to SSRIs may affect DNA methylation (DNAme) in the human placenta, an epigenetic mark that is established during development and is associated with gene expression. Chorionic villus...

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PMID: 36585414
DOI: 10.1038/s41598-022-26071-8

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