Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Prenatal exposure to maternal depressed mood and the MTHFR C677T variant affect SLC6A4 methylation in infants at birth.

PloS one - 16 Aug 2010

Devlin Angela M, Brain Ursula, Austin Jehannine, Oberlander Tim F

Abstract excerpt

BACKGROUND: Prenatal and early postnatal exposure to maternal depression may "program" childhood behavior via epigenetic processes such as DNA methylation. Methylenetetrahydro-folate reductase (MTHFR) is an important enzyme in the generation of methyl groups for DNA methylation. The common MTHFR C677T variant is associated with depression in men and non-pregnant women, and with global changes in DNA methylation....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Brain-Derived Neurotrophic Factor
Share to Depression

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA Methylation

Share to Maternal Exposure

Share to Methylenetetrahydrofolate Reductase (NADPH2)

Share to Mothers

Share to Parturition

Share to Serotonin Plasma Membrane Transport Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 20808944
DOI: 10.1371/journal.pone.0012201
PMCID: PMC2922376

Genes

MTHFR
BDNF

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Prenatal exposure to maternal depressed mood and the MTHFR C677T variant affect SLC6A4 methylation in infants at birth.PMID 20808944Read ↗

Epigenetic Alterations and Prenatal Maternal DepressionSemantic proximity Read ↗

Association between maternal depression during pregnancy and newborn DNA methylationSemantic proximity Read ↗

Genome-wide DNA methylation in neonates exposed to maternal depression, anxiety, or SSRI medication during pregnancySemantic proximity Read ↗

Effects of prenatal exposure to (es)citalopram and maternal depression during pregnancy on DNA methylation and child neurodevelopmentSemantic proximity Read ↗

Association between Maternal Depression during Pregnancy and Newborn DNA MethylationSemantic proximity Read ↗

Profiling placental DNA methylation associated with maternal SSRI treatment during pregnancySemantic proximity Read ↗

DNA methylation in neonates born to women receiving psychiatric careSemantic proximity Read ↗

A prospective study to explore the relationship between MTHFR C677T genotype, physiological folate levels, and postpartum psychopathology in at-risk women.Semantic proximity Read ↗

Profiling placental DNA methylation associated with maternal SSRI treatment during pregnancySemantic proximity Read ↗

Folic acid supplementation during pregnancy may protect against depression 21 months after pregnancy, an effect modified by MTHFR C677T genotype.Semantic proximity Read ↗

Depression in pregnancy, infant birth weight and DNA methylation of imprint regulatory elementsSemantic proximity Read ↗

Prenatal maternal antidepressants, anxiety, and depression and offspring DNA methylation: epigenome-wide associations at birth and persistence into early childhoodSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.