Article
Canalization and plasticity in psychopathology.
Neuropharmacology - 15 Mar 2023
Carhart-Harris R L, Chandaria S, Erritzoe D E, Gazzaley A, Girn M, Kettner H, Mediano P A M, Nutt D J, Rosas F E, Roseman L, Timmermann C, Weiss B, Zeifman R J, Friston K J
Abstract excerpt
This theoretical article revives a classical bridging construct, canalization, to describe a new model of a general factor of psychopathology. To achieve this, we have distinguished between two types of plasticity, an early one that we call 'TEMP' for 'Temperature or Entropy Mediated Plasticity', and another, we call 'canalization', which is close to Hebbian plasticity. These two forms of plasticity can be most...
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