Article
Transcription of cspA, the gene for the major cold-shock protein of Escherichia coli, is negatively regulated at 37 degrees C by the 5'-untranslated region of its mRNA.
FEMS microbiology letters - 1 Jul 1999
Fang L, Xia B, Inouye M
Abstract excerpt
The gene for CspA, the major cold-shock protein in Escherichia coli, is tightly regulated at both optimal and low temperatures. While CspA is drastically induced after temperature downshift, it is hardly detectable at 37 degrees C. Here we demonstrate that the deletion of parts of the 5'-untranslated region (5'-UTR) of the cspA mRNA results in constitutive expression of CspA at 37 degrees C. By analyzing the...
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