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Article

A novel technology for home monitoring of lupus nephritis that tracks the pathogenic urine biomarker ALCAM

8 Dec 2022

Abstract excerpt

Introduction: The gold standard for diagnosis of active lupus nephritis (ALN), a kidney biopsy, is invasive with attendant morbidity and cannot be serially repeated. Urinary ALCAM (uALCAM) has shown high diagnostic accuracy for renal pathology activity in ALN patients. Methods: Lateral flow assays (LFA) for assaying uALCAM were engineered using persistent luminescent nanoparticles, read by a smartphone. The...

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PMID: 36569940
DOI: 10.3389/fimmu.2022.1044743

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