Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Quantum Tunnelling Effects in the Guanine-Thymine Wobble Misincorporation via Tautomerism.

The journal of physical chemistry letters - 12 Jan 2023

Slocombe Louie, Winokan Max, Al-Khalili Jim, Sacchi Marco

Abstract excerpt

The misincorporation of a noncomplementary DNA base in the polymerase active site is a critical source of replication errors that can lead to genetic mutations. In this work, we model the mechanism of wobble mispairing and the subsequent rate of misincorporation errors by coupling first-principles quantum chemistry calculations to an open quantum systems master equation. This methodology allows us to accurately...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to DNA
Share to Guanine
Share to Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Protons

Share to Quantum Theory

Share to Thymine

Source

Open in PubMed Open full text

Identifiers

PMID: 36562711
DOI: 10.1021/acs.jpclett.2c03171
PMCID: PMC9841559

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Quantum Tunnelling Effects in the Guanine-Thymine Wobble Misincorporation via Tautomerism.PMID 36562711Read ↗

On genetic information uncertainty and the mutator phenotype in cancer.Semantic proximity Read ↗

Single Amino Acid Mutation Controls Hole Transfer Dynamics in DNA-Methyltransferase HhaI Complexes.Semantic proximity Read ↗

Quantum mechanics as a tool to decipher the mutational landscape of human disease.Semantic proximity Read ↗

Distinctive Formation of a DNA-Protein Cross-Link during the Repair of DNA Oxidative Damage: Insights into Human Disease from MD Simulations and QM/MM Calculations.Semantic proximity Read ↗

Mechanism of the Glycosidic Bond Cleavage of Mismatched Thymine in Human Thymine DNA Glycosylase Revealed by Classical Molecular Dynamics and Quantum Mechanical/Molecular Mechanical Calculations.Semantic proximity Read ↗

Environment assisted quantum model for studying RNA-DNA-error correlation created due to the base tautomery.Semantic proximity Read ↗

Correlation between Charge Transport and Base Excision Repair in the MutY-DNA Glycosylase.Semantic proximity Read ↗

Mutation Mechanism In DNA: Non-Hermitian ApproachSemantic proximity Read ↗

[Quantum chemical study of tautomery in nucleic acid bases and the problem of mutations].Semantic proximity Read ↗

Effects of the Y432S Cancer-Associated Variant on the Reaction Mechanism of Human DNA Polymerase κ.Semantic proximity Read ↗

Mutagenicity associated with O6-methylguanine-DNA damage and mechanism of nucleotide flipping by AGT during repair.Semantic proximity Read ↗

The relationship between mutation rates for the (C-G)-->(T-A) transition and features of T-G mispair structures in different neighbor environments, determined by free energy molecular mechanics.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.