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Article

On genetic information uncertainty and the mutator phenotype in cancer.

Bio Systems - 1 Jan 2000

Chan Jason Yongsheng

Abstract excerpt

Recent evidence supports the existence of a mutator phenotype in cancer cells, although the mechanistic basis remains unknown. In this paper, it is shown that this enhanced genetic instability is generated by an amplified measurement uncertainty on genetic information during DNA replication. At baseline, an inherent measurement uncertainty implies an imprecision of the recognition, replication and transfer...

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Identifiers

PMID: 22197792
DOI: 10.1016/j.biosystems.2011.12.002

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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