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Article

Synthesis and Structural Optimization of 2,7,9-Trisubstituted purin-8-ones as FLT3-ITD Inhibitors.

International journal of molecular sciences - 18 Dec 2022

Tomanová Monika, Kozlanská Karolína, Jorda Radek, Jedinák Lukáš, Havlíková Tereza, Řezníčková Eva, Peřina Miroslav, Klener Pavel, Dolníková Alexandra, Cankař Petr, Kryštof Vladimír

Abstract excerpt

Therapy of FLT3-positive acute myeloid leukemia still remains complicated, despite the availability of newly approved kinase inhibitors. Various strategies to avoid the reduced efficacy of therapy have been explored, including the development of dual targeting compounds, which inhibit FLT3 and another kinase necessary for the survival and proliferation of AML cells. We have designed new 2,7,9-trisubstituted...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 36555810
DOI: 10.3390/ijms232416169
PMCID: PMC9782245

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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