Article
Effect of genetic polymorphisms rs2301113 and rs2057482 in the expression of HIF-1α protein in periodontal ligament fibroblasts subjected to compressive force.
Journal of applied oral science : revista FOB - 1 Jan 2023
Küchler Erika Calvano, Teodoro Vinicius Broska, Schröder Agnes, Nazet Ute, Meger Michelle Nascimento, Kunz Patricia Valéria Manozzo, Baratto-Filho Flares, Spanier Gerrit, Scariot Rafaela, Proff Peter, Kirschneck Christian
Abstract excerpt
OBJECTIVE: Many genes and signaling molecules are involved in orthodontic tooth movement, with mechanically and hypoxically stabilized HIF-1α having been shown to play a decisive role in periodontal ligament signaling during orthodontic tooth movement. Thus, this in vitro study aimed to investigate if genetic polymorphisms in HIF1A (Hypoxia-inducible factor α-subunits) influence the expression pattern of HIF-1α...
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