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Calcium-Zinc Phosphate Chemical Conversion Coating Facilitates the Osteointegration of Biodegradable Zinc Alloy Implants by Orchestrating Macrophage Phenotype.

Advanced healthcare materials - 1 Apr 2023

Zhao Da-Wang, Du Chun-Miao, Zuo Kang-Qing, Zhao Yi-Xiang, Xu Xiao-Qian, Li Yi-Bo, Tian Shuai, Yang Hong-Ru, Lu Yu-Peng, Cheng Lei, Xiao Gui-Yong

Abstract excerpt

Zinc (Zn) alloys provide a new generation for orthopedic applications due to their essential physiological effects and promising degradation properties. However, excessive release of Zn ions (Zn2+ ) during degradation and the severe inflammatory microenvironment are not conducive to osseointegration, which is determined by the characteristics of the implant surface. Therefore, it is essential to modulate the...

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PMID: 36528867
DOI: 10.1002/adhm.202202537

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