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Article

Effect of EGFR amplification on the prognosis of EGFR-mutated advanced non-small-cell lung cancer patients: a prospective observational study.

BMC cancer - 17 Dec 2022

Peng Duanyang, Liang Pingan, Zhong Congying, Xu Peng, He Yanqing, Luo Yuxi, Wang Xia, Liu Anwen, Zeng Zhimin

Abstract excerpt

BACKGROUND: Epidermal growth factor receptor (EGFR) amplification refers to the copy number increase of EGFR gene, and is often identified as a "bypass" way of Epidermal growth factor receptor Tyrosine kinase inhibitors (EGFR-TKI) resistance. We aimed to explore the effect of EGFR amplification on EGFR mutation treatment-naive advanced non-squamous non-small cell lung cancer (NSCLC) patients. METHODS: We...

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Identifiers

PMID: 36528578
DOI: 10.1186/s12885-022-10390-0
PMCID: PMC9758842

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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