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Effects of biological sex and pregnancy in experimental autoimmune encephalomyelitis: It’s complicated

28 Nov 2022

Abstract excerpt

Experimental autoimmune encephalomyelitis (EAE) can be induced in many animal strains by inoculation with central nervous system antigens and adjuvant or by the passive transfer of lymphocytes reactive with these antigens and is widely used as an animal model for multiple sclerosis (MS). There are reports that female sex and pregnancy affect EAE. Here we review the effects of biological sex and the effects of...

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PMID: 36518769
DOI: 10.3389/fimmu.2022.1059833

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