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Article

Detection of chromosomal alteration after infusion of gene-edited allogeneic CAR T cells

13 Dec 2022

Abstract excerpt

A chromosome 14 inversion was found in a patient who developed bone marrow aplasia following treatment with allogeneic chimeric antigen receptor (CAR) Tcells containing gene edits made with transcription activator-like effector nucleases (TALEN). TALEN editing sites were not involved at either breakpoint. Recombination signal sequences (RSSs) were found suggesting recombination-activating gene (RAG)-mediated...

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PMID: 36518079
DOI: 10.1016/j.ymthe.2022.12.004

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