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Article

KRAS G12D mutation eliminates reactive oxygen species through the Nrf2/CSE/H 2S axis and contributes to pancreatic cancer growth.

Acta biochimica et biophysica Sinica - 25 Nov 2022

Fan Kun, Zhang Shulong, Ni Xiaojian, Shen Sheng, Wang Jiwen, Sun Wentao, Suo Tao, Liu Han, Ni Xiaoling, Liu Houbao

Abstract excerpt

In pancreatic cancer, KRAS G12D can trigger pancreatic cancer initiation and development. Rapid tumor growth is often accompanied by excess intracellular reactive oxygen species (ROS) production, which is unfavorable to tumor. However, the regulation of intracellular ROS levels in KRAS mutant pancreatic cancer remains unclear. In this study, we establish BxPC3 stable cell strains expressing KRAS wild type (WT)...

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Identifiers

PMID: 36514219
DOI: 10.3724/abbs.2022173
PMCID: PMC9828102

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