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Article

Laforin targets malin to glycogen in Lafora progressive myoclonus epilepsy

13 Dec 2022

Abstract excerpt

Glycogen is the largest cytosolic macromolecule and is kept in solution through a regular system of short branches allowing hydration. This structure was thought to solely require balanced glycogen synthase and branching enzyme activities. Deposition of overlong branched glycogen in the fatal epilepsy Lafora disease (LD) indicated involvement of the LD gene products laforin and the E3 ubiquitin ligase malin in...

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Identifiers

PMID: 36511140
DOI: 10.1242/dmm.049802

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Related research

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Laforin targets malin to glycogen in Lafora progressive myoclonus epilepsyPMID 36511140Read ↗

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