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Article

Brain metastatic outgrowth and osimertinib resistance are potentiated by RhoA in EGFR-mutant lung cancer.

Nature communications - 12 Dec 2022

Adua Sally J, Arnal-Estapé Anna, Zhao Minghui, Qi Bowen, Liu Zongzhi Z, Kravitz Carolyn, Hulme Heather, Strittmatter Nicole, López-Giráldez Francesc, Chande Sampada, Albert Alexandra E, Melnick Mary-Ann, Hu Bomiao, Politi Katerina, Chiang Veronica, Colclough Nicola, Goodwin Richard J A, Cross Darren, Smith Paul, Nguyen Don X

Abstract excerpt

The brain is a major sanctuary site for metastatic cancer cells that evade systemic therapies. Through pre-clinical pharmacological, biological, and molecular studies, we characterize the functional link between drug resistance and central nervous system (CNS) relapse in Epidermal Growth Factor Receptor- (EGFR-) mutant non-small cell lung cancer, which can progress in the brain when treated with the CNS-penetrant...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 36509758
DOI: 10.1038/s41467-022-34889-z
PMCID: PMC9744876

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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