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Article

An EGFR L858R mutation identified in 1862 Chinese NSCLC patients can be a promising neoantigen vaccine therapeutic strategy.

Frontiers in immunology - 1 Jan 2022

Lin Jing, Liu Jun, Hao Shi-Guang, Lan Bin, Zheng Xiao-Bin, Xiong Jia-Ni, Zhang Ying-Qian, Gao Xuan, Chen Chuan-Ben, Chen Ling, Huang Yu-Fang, Luo Hong, Yi Yu-Ting, Yi Xin, Lu Jian-Ping, Zheng Xiong-Wei, Chen Gang, Wang Xue-Feng, Chen Yu

Abstract excerpt

Background: This study aimed to develop a vaccine that targets mutation-derived neoantigen in Chinese non-small-cell lung cancer (NSCLC). Methods: A cohort of 1862 Chinese NSCLC patients who underwent targeted sequencing with a 1021-gene panel was investigated. HLA typing was done using OptiType v1.0 and neoantigens were predicted by netMHCpan v4.0. HLA LOH was inferred using the lohhla algorithm and TMB were...

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Identifiers

PMID: 36505399
DOI: 10.3389/fimmu.2022.1022598
PMCID: PMC9727402

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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