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Many Functions of Telomerase Components: Certainties, Doubts, and Inconsistencies

2 Dec 2022

Abstract excerpt

A growing number of studies have evidenced non-telomeric functions of "telomerase". Almost all of them, however, investigated the non-canonical effects of the catalytic subunit TERT, and not the telomerase ribonucleoprotein holoenzyme. These functions mainly comprise signal transduction, gene regulation and the increase of anti-oxidative systems. Although less studied, TERC (the RNA component of telomerase) has...

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Share to Genetics, Aging, and Longevity in Model Organisms
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PMID: 36499514
DOI: 10.3390/ijms232315189

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