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Effects of food and race on the pharmacokinetics of lazertinib in healthy subjects and patients with EGFR mutation-positive advanced non-small cell lung cancer.

Lung cancer (Amsterdam, Netherlands) - 1 Jan 2023

Huh Ki Young, Lim Yeji, Yoon Deok Yong, Hwang Jun Gi, Sim Sujin, Kang Jiah, Wang Jangyoung, Kim Mikyung, Jang Seong Bok, Shreeve S Martin, Mehta Jaydeep, Haddish-Berhane Nahor, Oh Jaeseong, Lee SeungHwan, Yu Kyung-Sang

Abstract excerpt

OBJECTIVES: Lazertinib is a potent, irreversible, brain-penetrant, mutant-selective, and wild type-sparing third-generation epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor indicated for advanced non-small cell lung cancer (NSCLC). The study aimed to evaluate the effects of food and race on the pharmacokinetics (PK) of lazertinib from a healthy volunteer trial and PK data from NSCLC patients with...

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Identifiers

PMID: 36495784
DOI: 10.1016/j.lungcan.2022.11.021

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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