Strain diversity and gene mutations associated with presumptive multidrug-resistant Mycobacterium tuberculosis complex isolates in Northwest Ethiopia.

doi:10.1016/j.jgar.2022.11.012

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Strain diversity and gene mutations associated with presumptive multidrug-resistant Mycobacterium tuberculosis complex isolates in Northwest Ethiopia.

Journal of global antimicrobial resistance - 1 Mar 2023

Ejo Mebrat, Torrea Gabriela, Diro Ermias, Abebe Ayenesh, Kassa Meseret, Girma Yilak, Tesfa Eyasu, Ejigu Kefialew, Uwizeye Cecile, Gehre Florian, de Jong Bouke C, Rigouts Leen

Abstract excerpt

OBJECTIVES: In this study, we assessed the genetic diversity and gene mutations that confer resistance to rifampicin (RIF), isoniazid (INH), fluoroquinolone (FQ), and second-line injectable (SLI) drugs in RIF-resistant (RR)/multidrug-resistant tuberculosis (MDR-TB) isolates in Northwest Ethiopia. METHODS: Spoligotyping was used to assign isolates to TB lineages (Ls), and Hain line probe assays were used to detect...

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