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Article

Androgen-regulated MafB drives cell migration via MMP11-dependent extracellular matrix remodeling in mice

16 Nov 2022

Abstract excerpt

While androgen is considered a pivotal regulator of sexually dimorphic development, it remains unclear how it orchestrates the differentiation of reproductive organs. Using external genitalia development as a model, we showed that androgen, through the transcription factor MafB , induced cell migration by remodeling the local extracellular matrix (ECM), leading to increased cell contractility and focal adhesion...

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PMID: 36465133
DOI: 10.1016/j.isci.2022.105609

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