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Identification of Human Monkeypox Virus Genome Deletions That Impact Diagnostic Assays

29 Nov 2022

Abstract excerpt

In August 2022, the Los Angeles County Department of Public Health initiated an investigation into human monkeypox virus (MPXV) cases with unusual results from a multiplex laboratory-developed test used by Quest Diagnostics, which is based on the CDC nonvariola Orthopoxvirus (NVO) (1) and MPXV clade II (MPXV-WA) (2) real-time PCR assays. These specimens returned NVO–positive and either MPXV-WA–negative or...

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PMID: 36445125
DOI: 10.1128/jcm.01655-22

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