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Extrinsic cell death pathway plasticity: a driver of clonal evolution in cancer?

26 Nov 2022

Abstract excerpt

Human cancers are known to adhere to basic evolutionary principles. During their journey from early transformation to metastatic disease, cancer cell populations have proven to be remarkably adaptive to different forms of intra- and extracellular selective pressure, including nutrient scarcity, oxidative stress, and anti-cancer immunity. Adaption may be achieved via the expansion of clones bearing driver...

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PMID: 36435845
DOI: 10.1038/s41420-022-01251-7

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