EGCG ameliorates neuronal and behavioral defects by remodeling gut microbiota and TotM expression in Drosophila models of Parkinson’s disease

Abstract excerpt

Abstract Parkinson’s disease (PD) is the second most common neurodegenerative disease. Eigallocatechin‐3‐gallate (EGCG), the major polyphenol in green tea, is known to exert a beneficial effect on PD patients. Although some mechanisms were suggested to underlie this intervention, it remains unknown if the EGCG‐mediated protection was achieved by remodeling gut microbiota. In the present study, 0.1 mM or 0.5 mM...

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