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Optimization of Bangladesh and Malaysian genotype recombinant reporter Nipah viruses for in vitro antiviral screening and in vivo disease modeling.

Antiviral research - 1 Nov 2024

Lo Michael K, Jain Shilpi, Davies Katherine A, Sorvillo Teresa E, Welch Stephen R, Coleman-McCray JoAnn D, Chatterjee Payel, Hotard Anne L, O'Neal Troy, Flint Mike, Ai Huiwang, Albariño Cesar G, Spengler Jessica R, Montgomery Joel M, Spiropoulou Christina F

Abstract excerpt

Nipah virus (NiV) causes near-annual outbreaks of fatal encephalitis and respiratory disease in South Asia with a high mortality rate (∼70%). Since there are no approved therapeutics for NiV disease in humans, the WHO has designated NiV and henipaviral diseases priority pathogens for research and development. We generated a new recombinant green fluorescent reporter NiV of the circulating Bangladesh genotype...

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Identifiers

PMID: 39326503
DOI: 10.1016/j.antiviral.2024.106013
PMCID: PMC11772256

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