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Mitochondrial fission and bioenergetics mediate human lung fibroblast durotaxis

24 Nov 2022

Abstract excerpt

Pulmonary fibrosis is characterized by stiffening of the extracellular matrix. Fibroblasts migrate in the direction of greater stiffness, a phenomenon termed durotaxis. The mechanically guided fibroblast migration could be a crucial step in the progression of lung fibrosis. In this study, we found primary human lung fibroblasts sense increasing matrix stiffness with a change of mitochondrial dynamics in favor of...

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PMID: 36422990
DOI: 10.1172/jci.insight.157348

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