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Article

Role of PARP Inhibitors in Cancer Biology and Therapy

1 Jul 2012

Abstract excerpt

Deeper understanding of DNA repair mechanisms and their potential value as therapeutic targets in oncology heralded the clinical development of poly(ADP-ribose) polymerase (PARP) inhibitors. Although initially developed to exploit synthetic lethality in models of cancer associated with defective DNA repair, our burgeoning knowledge of PARP biology has resulted in these agents being exploited both in cancer with...

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PMID: 22788767
DOI: 10.2174/092986712802002464

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