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Article

A non-coding GWAS variant impacts anthracycline-induced cardiotoxic phenotypes in human iPSC-derived cardiomyocytes.

Nature communications - 22 Nov 2022

Wu Xi, Shen Fei, Jiang Guanglong, Xue Gloria, Philips Santosh, Gardner Laura, Cunningham Geneva, Bales Casey, Cantor Erica, Schneider Bryan Paul

Abstract excerpt

Anthracyclines, widely used to treat breast cancer, have the potential for cardiotoxicity. We have previously identified and validated a germline single nucleotide polymorphism, rs28714259, associated with an increased risk of anthracycline-induced heart failure. We now provide insights into the mechanism by which rs28714259 might confer increased risk of cardiac damage. Using hiPSC-derived cardiomyocyte cell...

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Source

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Identifiers

PMID: 36418322
DOI: 10.1038/s41467-022-34917-y
PMCID: PMC9684507

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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