Article
Novel non-stimulants rescue hyperactive phenotype in an adgrl3.1 mutant zebrafish model of ADHD.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology - 1 Jul 2023
Sveinsdóttir Hildur Sóley, Christensen Christian, Þorsteinsson Haraldur, Lavalou Perrine, Parker Matthew O, Shkumatava Alena, Norton William H J, Andriambeloson Emile, Wagner Stéphanie, Karlsson Karl Ægir
Abstract excerpt
ADHD is a highly prevalent neurodevelopmental disorder. The first-line therapeutic for ADHD, methylphenidate, can cause serious side effects including weight loss, insomnia, and hypertension. Therefore, the development of non-stimulant-based therapeutics has been prioritized. However, many of these also cause other effects, most notably somnolence. Here, we have used a uniquely powerful genetic model and unbiased...
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