Genetic liability to bipolar disorder and body mass index: A bidirectional two-sample Mendelian randomization study.

Abstract excerpt

OBJECTIVES: Bipolar disorder is associated with increased body mass index (BMI), but it remains undetermined if this association is causal and, if so, in which direction it goes. Here, we sought to answer these questions using bidirectional two-sample Mendelian randomization, a method from genetic epidemiology that uses data from genome-wide association studies (GWAS) to examine whether a risk factor is causal...

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