Article
Mutations in the WLS are associated with dental anomalies, torus palatinus, and torus mandibularis.
European journal of orthodontics - 31 May 2023
Kantaputra Piranit, Tripuwabhrut Kanich, Jatooratthawichot Peeranat, Adisornkanj Ploy, Hatsadaloi Athiwat, Porntrakoolsaree Nop, Kaewgaya Massupa, Olsen Bjorn, Tongsima Sissades, Ngamphiw Chumpol, Ketudat Cairns James R
Abstract excerpt
BACKGROUND: Canonical and non-canonical WNT signaling are important for odontogenesis. WNT ligand secretion mediator (WLS; MIM611514) is required to transport lipid-modified WNT proteins from the Golgi to the cell membrane, where canonical and non-canonical WNT proteins are released into the extracellular milieu. Biallelic pathogenic variants in WLS are implicated in autosomal recessive Zaki syndrome (ZKS; MIM...
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