Article
Genetic Heterogeneity Shapes Brain Connectivity in Psychiatry.
Biological psychiatry - 1 Jan 2023
Moreau Clara A, Harvey Annabelle, Kumar Kuldeep, Huguet Guillaume, Urchs Sebastian G W, Douard Elise A, Schultz Laura M, Sharmarke Hanad, Jizi Khadije, Martin Charles-Olivier, Younis Nadine, Tamer Petra, Rolland Thomas, Martineau Jean-Louis, Orban Pierre, Silva Ana Isabel, Hall Jeremy, van den Bree Marianne B M, Owen Michael J, Linden David E J, Labbe Aurelie, Lippé Sarah, Bearden Carrie E, Almasy Laura, Glahn David C, Thompson Paul M, Bourgeron Thomas, Bellec Pierre, Jacquemont Sebastien
Abstract excerpt
BACKGROUND: Polygenicity and genetic heterogeneity pose great challenges for studying psychiatric conditions. Genetically informed approaches have been implemented in neuroimaging studies to address this issue. However, the effects on functional connectivity of rare and common genetic risks for psychiatric disorders are largely unknown. Our objectives were to estimate and compare the effect sizes on brain...
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