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Article

Characterization of Clinical Cases of Malignant PEComa via Comprehensive Genomic Profiling of DNA and RNA.

Oncology - 1 Jan 2020

Akumalla Saranya, Madison Russell, Lin Douglas I, Schrock Alexa B, Yakirevich Evgeny, Rosenzweig Mark, Balar Arjun V, Frampton Garrett M, Edgerly Claire, Erlich Rachel L, Miller Vincent A, Ganesan Shridar, Ross Jeffrey S, Ali Siraj M

Abstract excerpt

PURPOSE: Perivascular epithelioid cell tumor (PEComa) is a rare mesenchymal soft tissue neoplasm often linked to mTOR pathway activation via TSC2 mutation. We analyzed a series of 31 consecutive metastatic PEComa (mPEComa) cases using a combined DNA/RNA hybrid capture-based comprehensive genomic profiling (CGP) assay to assess the genomic landscape of mPEComa. PATIENTS AND METHODS: Formalin-fixed,...

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PMID: 32966992
DOI: 10.1159/000510241

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