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SARS-CoV-2 spike conformation determines plasma neutralizing activity elicited by a wide panel of human vaccines

10 Nov 2022

Abstract excerpt

Numerous safe and effective coronavirus disease 2019 vaccines have been developed worldwide that use various delivery technologies and engineering strategies. We show here that vaccines containing prefusion-stabilizing S mutations elicit antibody responses in humans with enhanced recognition of S and the S 1 subunit relative to postfusion S as compared with vaccines lacking these mutations or natural infection....

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PMID: 36356052
DOI: 10.1126/sciimmunol.adf1421

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