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MYC and TP53 Alterations but Not MAPK Pathway Mutations Are Common Oncogenic Mechanisms in Follicular Dendritic Cell Sarcomas.

Archives of pathology & laboratory medicine - 1 Aug 2023

Frigola Gerard, Bühler Marco, Marginet Marta, Enjuanes Anna, Nadeu Ferran, Papaleo Natalia, Salido Marta, Haralambieva Eugenia, Alamo José, Garcia-Bragado Federico, Álvarez Ramiro, Ramos Rafael, Aldecoa Iban, Campo Elías, Colomo Lluis, Balagué Olga

Abstract excerpt

CONTEXT.—: Despite their stromal origin, follicular dendritic cells (FDCs) share many functions with hematopoietic system cells. FDC neoplasms are currently classified by the World Health Organization along with those of a histiocytic nature. However, the molecular alterations driving oncogenesis in FDC sarcomas (FDCSs) are beginning to be unveiled and do not seem to concur with those described in histiocytic...

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PMID: 36355424
DOI: 10.5858/arpa.2021-0517-OA

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