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Molecular Genetics of Prostate Cancer and Role of Genomic Testing

13 Oct 2022

Abstract excerpt

Prostate cancer (PCa) is characterized by profound genomic heterogeneity. Recent advances in personalized treatment entail an increasing need of genomic profiling. For localized PCa, gene expression assays can support clinical decisions regarding active surveillance and adjuvant treatment. In metastatic PCa, homologous recombination deficiency, microsatellite instability-high (MSI-H), and CDK12 deficiency...

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PMID: 36344179
DOI: 10.1016/j.path.2022.08.002

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