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Article

Generation of induced pluripotent stem cells (iPSC) from an atrial fibrillation patient carrying a PITX2 p.M200V mutation.

Stem cell research - 1 Oct 2017

Mora Cristina, Serzanti Marialaura, Giacomelli Alessio, Beltramone Silvia, Marchina Eleonora, Bertini Valeria, Piovani Giovanna, Refsgaard Lena, Olesen Morten Salling, Cortellini Venusia, Dell'Era Patrizia

Abstract excerpt

Atrial fibrillation (AF) is the most common sustained arrhythmia associated with several cardiac risk factors, but increasing evidences indicated a genetic component. Indeed, genetic variations of the specific PITX2 gene have been identified in patients with early-onset AF. To investigate the molecular mechanisms underlying AF, we reprogrammed to pluripotency polymorphonucleated leukocytes isolated from the blood...

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Identifiers

PMID: 29034898
DOI: 10.1016/j.scr.2017.08.007

Genes

PITX2

Variants

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Research trail→

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Generation of induced pluripotent stem cells (iPSC) from an atrial fibrillation patient carrying a PITX2 p.M200V mutation.PMID 29034898Read ↗

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