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Article

Assessing the causal relationships between gout and hypertension: a bidirectional Mendelian randomisation study with coarsened exposures.

Arthritis research & therapy - 29 Oct 2022

Lai Benjamin, Yu Huang-Ping, Chang Yu-Jing, Wang Liang-Chin, Chen Che-Kai, Zhang Weiya, Doherty Michael, Chang Shang-Hung, Hsu Jun-Te, Yu Kuang-Hui, Kuo Chang-Fu

Abstract excerpt

OBJECTIVES: Observational studies have demonstrated associations between gout and hypertension, but whether they are causal remains unclear. Our work aims to assess the causal relationship between gout and hypertension. METHODS: We obtained genetic information from the Taiwan Biobank, including 88,347 participants and 686,439 single-nucleotide polymorphisms (SNPs). A novel model of Mendelian randomisation (MR)...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 36309757
DOI: 10.1186/s13075-022-02933-4
PMCID: PMC9617405

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