Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Synthesis and Chemopreventive Potential of 5-FU/Genistein Hybrids on Colorectal Cancer Cells

21 Oct 2022

Abstract excerpt

A series of 5-FU-Genistein hybrids were synthesized and their structures were elucidated by spectroscopic analysis. The chemopreventive potential of these compounds was evaluated in human colon adenocarcinoma cells (SW480 and SW620) and non-malignant cell lines (HaCaT and CHO-K1). Hybrid 4a displayed cytotoxicity against SW480 and SW620 cells with IC50 values of 62.73 ± 7.26 µM and 50.58 ± 1.33 µM, respectively;...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Diet, Metabolism, and Disease
Share to Genomics, phytochemicals, and oxidative stress
Share to Phytoestrogen effects and research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 36297411
DOI: 10.3390/ph15101299

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Synthesis and Chemopreventive Potential of 5-FU/Genistein Hybrids on Colorectal Cancer CellsPMID 36297411Read ↗

New Hybrids Based on Curcumin and Resveratrol: Synthesis, Cytotoxicity and Antiproliferative Activity against Colorectal Cancer CellsSemantic proximity Read ↗

Characterization of novel natural compound derivatives with cancer-selective cytotoxicitySemantic proximity Read ↗

Induction of Apoptosis and Cell-Cycle Arrest in Human Colon-Cancer Cells by Whole-Grain Alkylresorcinols via Activation of the p53 PathwaySemantic proximity Read ↗

Synthesis of Novel Hybrids of Thymoquinone and Artemisinin with High Activity and Selectivity Against Colon CancerSemantic proximity Read ↗

Ginsenoside compound K, not Rb1, possesses potential chemopreventive activities in human colorectal cancerSemantic proximity Read ↗

Identification of Synergistic Interaction Between Cannabis-Derived Compounds for Cytotoxic Activity in Colorectal Cancer Cell Lines and Colon Polyps That Induces Apoptosis-Related Cell Death and Distinct Gene ExpressionSemantic proximity Read ↗

Morindone as a potential therapeutic compound targeting TP53 and KRAS mutations in colorectal cancer cells.Semantic proximity Read ↗

Anticancer Activity of a Novel High Phenolic Sorghum Bran in Human Colon Cancer CellsSemantic proximity Read ↗

A novel resveratrol derivative selectively inhibits the proliferation of colorectal cancer cells with KRAS mutation.Semantic proximity Read ↗

Synthesis and evaluation of apoptosis induction of thienopyrimidine compounds on KRAS and BRAF mutated colorectal cancer cell lines.Semantic proximity Read ↗

Cytotoxic Effect of Resveratrol on Colorectal Cancer Cell LineSemantic proximity Read ↗

Differential antiproliferative mechanisms of novel derivative of benzimidazo[1,2- α ]quinoline in colon cancer cells depending on their p53 statusSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.