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Article

Effects of Sex and Obesity on LEP Variant and Leptin Level Associations in Intervertebral Disc Degeneration.

International journal of molecular sciences - 14 Oct 2022

Chen Hsing-Hong, Hsu Hsien-Ta, Liao Mei-Hsiu, Teng Ming-Sheng

Abstract excerpt

Intervertebral disc degeneration (IVDD), for which obesity and genetics are known risk factors, is a chronic process that alters the structure and function of the intervertebral discs (IVD). Circulating leptin is positively correlated with body weight and is often measured to elucidate the pathogenesis of IVD degeneration. In this study, we examined the associations of LEP single nucleotide polymorphisms (SNPs)...

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Identifiers

PMID: 36293132
DOI: 10.3390/ijms232012275
PMCID: PMC9603873

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