Article
[Clinicopathological features and prognosis of gastrointestinal stromal tumor with PDGFRA-D842V mutation].
Zhonghua wei chang wai ke za zhi = Chinese journal of gastrointestinal surgery - 25 Sept 2020
Li X Q, Tu L, Wang M, Ma X L, Yang L X, Shen Y Y, Zhuang C, Zhao W Y, Qiu J F, Zhao G, Cao H
Abstract excerpt
Objective: Platelet-derived growth factor alpha (PDGFRA) mutations are respectively rare in gastrointestinal stromal tumors (GIST). Most GIST with PDGFRA exon 18 mutations including D842V mutation are highly resistant to imatinib. The treatment of GIST harboring PDGFRA primary drug-resistant mutation is a major challenge. This article aims to investigate clinicopathologic features of GIST with PDGFRA-D842V...
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