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Antiepileptic drugs are endocrine disruptors for the human fetal testisex vivo

28 Jul 2023

Abstract excerpt

Valproic acid (VPA) has long been the most widely used antiepileptic drug (AED) for the treatment of epilepsy, bipolar psychiatric disorders, and migraine. However, long-term VPA treatment has several adverse effects on the male reproductive system notably on endocrine functions and/or spermatic parameters. In utero exposure of the fetus to VPA is well known to be associated with a higher risk of several...

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PMID: 37505509
DOI: 10.1093/toxsci/kfad076

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