Article
Influence of ABCB1, CYP3A5 and CYP3A4 gene polymorphisms on prothrombin time and the residual equilibrium concentration of rivaroxaban in patients with non-valvular atrial fibrillation in real clinical practice.
Pharmacogenetics and genomics - 1 Dec 2022
Sychev Dmitry Alekseevitch, Sokolov Aleksey Vladimirovich, Reshetko Olga Vilorovna, Fisenko Vladimir Petrovich, Sychev Igor Nikolaevich, Grishina Elena Anatolievna, Bochkov Pavel Olegovich, Shevchenko Roman Vladimirovich, Abdullaev Sherzod Pardaboevich, Denisenko Natalia Pavlovna, Ivashchenko Dmitry Vladimirovich, Sozaeva Zhannet Alimovna, Kachanova Anastasia Alekseevna
Abstract excerpt
OBJECTIVE: The study of ABCB1 and CYP3A4/3A5 gene polymorphism genes is promising in terms of their influence on prothrombin time variability, the residual equilibrium concentration of direct oral anticoagulants (DOACs) in patients with atrial fibrillation and the development of new personalized approaches to anticoagulation therapy in these patients. The aim of the study is to evaluate the effect of ABCB1...
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