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DNA damage contributes to age‐associated differences in SARS‐CoV ‐2 infection

18 Oct 2022

Abstract excerpt

Coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is known to disproportionately affect older individuals. How aging processes affect SARS-CoV-2 infection and disease progression remains largely unknown. Here, we found that DNA damage, one of the hallmarks of aging, promoted SARS-CoV-2 infection in vitro and in vivo. SARS-CoV-2 entry was facilitated...

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PMID: 36254583
DOI: 10.1111/acel.13729

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