Article
Potential for diagnosis versus therapy monitoring of attention deficit hyperactivity disorder: a new epigenetic biomarker interacting with both genotype and auto-immunity.
European child & adolescent psychiatry - 1 Feb 2018
Adriani Walter, Romano Emilia, Pucci Mariangela, Pascale Esterina, Cerniglia Luca, Cimino Silvia, Tambelli Renata, Curatolo Paolo, Granstrem Oleg, Maccarrone Mauro, Laviola Giovanni, D'Addario Claudio
Abstract excerpt
In view of the need for easily accessible biomarkers, we evaluated in ADHD children the epigenetic status of the 5'-untranslated region (UTR) in the SLC6A3 gene, coding for human dopamine transporter (DAT). We analysed buccal swabs and sera from 30 children who met DSM-IV-TR criteria for ADHD, assigned to treatment according to severity. Methylation levels at six-selected CpG sites (among which, a CGGCGGCGG and a...
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