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Article

Molecular classification of endometrial carcinoma: a clinically oriented review

30 May 2022

Abstract excerpt

The Cancer Genome Atlas research network performed a genome-wide analysis of endometrial carcinomas in 2013 and classified tumours into four distinct subgroups: polymerase-ϵ ultramutated, microsatellite unstable hypermutated, copy-number low and copy-number high. These molecular alterations are mostly mutually exclusive as only about 3% of tumours exhibit more than one molecular signature. Apart from the...

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PMID: 35636924
DOI: 10.1136/jclinpath-2022-208345

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